Microglia are a type of immune cell whose dysfunction has been linked to development problems and diseases of the brain and central nervous system (CNS).
The study — which was led by the University Medical Center Groningen (UMCG) in the Netherlands and published in the journalFrontiers in Molecular Neuroscience — discovered that exercise was far less effective than restricting calorie intake at preventing the inflammatory activation of microglia brought on by aging.
Described as the “resident immune cells” of the brain and the rest of the CNS, microglia oversee many processes that underpin their development and function.
Microglia and aging-induced inflammation
Scientists have found that microglia play an essential role in the development of neurons, or nerve cells, as well as in the transmission of signals between neurons.
We also know that microglia monitor the functional tissues of the brain and the rest of the CNS and react to subtle changes in their microenvironments.